Seminar: Organic Chemistry, Natural Products | June 17 | 2.30 p.m.-3.30 p.m. | Room 1.3.20
Anna Przybył , Associate Professor, Department of Medicinal Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland
Impossible becomes possible – Application of spectroscopic methods for structural analysis of bioactive (-)-cytisine and its derivatives
Host: Ana Paula Paiva
Prof. Anna Przybył interests focus on the chemistry of natural products, particularly the chemistry of quinolizidine alkaloids and cinchona bark alkaloids.
Ongoing research topics include the synthesis, modification, chiral recognition, chiral resolution, catalytic asymmetric synthesis, analytics of enantiomers and spectroscopic analysis as well as the understanding of the biological activity of selected groups of alkaloids and their conjugates. Current research is focused on the use of quinolizidine alkaloids as leading compounds in the search for new inhibitors that will exhibit promising anticancer activities.
The antiproliferative properties of the new derivatives and conjugates are being analyzed by standard screening assays in vitro cellular system using selected human cancer cell lines and healthy cells as reference agents for testing the biological activity of the compounds. Studies on human cells are carried out in cooperation with the Hirszfeld Institute of Immunology and Experimental Therapy (Polish Academy of Sciences in Wroclaw).